Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice.

Following a single SQ injection (acute dosing), an increase in dose from 3 mg/kg to 5 mg/kg resulted in a proportional increase in plasma concentrations and AUC, though this increase did not reach statistical significance and only showed a trend ( Figure 2 and Table 1 ).

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