Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.

Metformin-educated CD8 + T cells from WT mice also showed a trend of increased mRNA expression for Sell ( CD62L ), Cpt1a and Tfam (mitochondrial transcription factor A) genes (Supplementary Fig. 5b ).

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This paralleled with a trend for lower bacterial load in the lungs of Mtb -infected TCRβδ −/− mice that received metformin-educated CD8 + T M cells compared with those receiving control CD8 + T M cells (1.4 log 10 reduction), although this did not reach statistical significance (Fig. 4h ).

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