Left atrial appendage closure in patients with a reduced left ventricular ejection fraction: results from the multicenter German LAARGE registry.

However, after adjustment for age, sex, chronic kidney disease, coronary artery disease, peripheral arterial disease, and diabetes mellitus, the effect of LVEF on the combined effectiveness outcome measure did not reach statistical significance any more (Table 5 ).

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Though prima facie, the combined event rate of all-cause deaths and non-fatal strokes showed a trend towards a higher incidence with LVEF reduction, this only reflects the expectable accompanying increase in cardiovascular comorbidity.

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