CMT-308, a Nonantimicrobial Chemically-Modified Tetracycline, Exhibits Anti-Melanogenic Activity by Suppression of Melanosome Export.

In cells maintained in the presence of α-MSH, CMT-308 showed a trend for reduction in ROS generation, although no significance was reached at any concentration ( Figure 4 D). 3.9.

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Next, our results on the effects of CMT-308 on tyrosinase activity of HEMn-DP cellular lysates showed a trend for reduction of activity by 23.53% ( Figure 6 D) at 10 μM, but this inhibition did not reach statistical significance. 3.11.

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