Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms.

All three index SNPs showed nominally significant association (p value < 0.016) in this second Colombian cohort, with the strongest signal being observed for rs115943328 in NCX3 (p value 3 × 10 −5 ).

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However, repetitive stimulation showed highly significant temporal summation, and the sensory phenotype did not serve as a clinical outcome but rather identified biologically relevant gene associations.

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We found strongly significant association for NCX3 (p value 3 × 10 −8 ) and weakly significant association for LINC00871 (p value 0.005) ( Table S1 ).

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