Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.

In contrast, Nlgn3 −/Y mice showed a trend towards requiring fewer first presentation trials (Mann–Whitney U = 76.5, adjusted p = 0.052, Figure 2(A) ) and completed significantly fewer correction trials (Mann–Whitney U = 66, adjusted p = 0.0365, Figure 2(B) ) than WT littermates before reaching the learning criterion.

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These differences did not reach statistical significance following correction for multiple testing at the session-level analysis ( Figures 4(C) and 5(C) ), but the task-level analysis revealed that Shank2 +/− and Shank2 −/− mice had significantly shorter latencies during visual discrimination (main effect of genotype: F (2,14) = 5.487; adjusted p = 0.03;

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