TREM2 protects from atherosclerosis by limiting necrotic core formation.

Macrophage uptake of Dil-labeled oxLDL was reduced in Trem2 −/− BMDMs and showed a trend toward increase in 4D9-treated macrophages (Fig. 3c and Supplementary Fig. 2 ).

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weekly) showed a clear trend toward decreased necrotic core formation, without inducing changes in lesion size or macrophage content (Extended Data Fig. 5b–e ).

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