Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease.

We observed a strong trend toward reduced tau pathology in the contralateral hippocampus of DMR7- and SKT82-treated mice compared to their respective IgG1 and IgG2b controls, although this did not quite reach statistical significance using two-tailed unpaired Student’s t-tests ( p = 0.069 and 0.077, respectively).

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Although there was considerable variability between animals, SKT82 and DMR7 treatment showed a trend towards lower insoluble phosphorylated tau in the ipsilateral and contralateral sides of AD-tau injected 5xFAD mice.

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