Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular disease.

Eur J Heart Fail · 2020 · PMC7675329 · PMID 33017071

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0.1000

closest p · 2.0× alpha

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boldest claim

The sentences

a strong trendP = 0.10so close (0.05 < p ≤ 0.1)

Interestingly, we also observed a strong trend towards an increased ACE2 mRNA expression in patients treated with MRAs ( P = 0.10) or beta‐blockers ( P = 0.08; online supplementary Table S2 ).

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did not reach statistical significanceno p-value reported

This increase was consistent across both patients treated with either ACEi or ARB although the latter did not reach statistical significance (online supplementary Figure S3A ).

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