Recent advances in clinical practice: colorectal cancer chemoprevention in the average-risk population.

11 12 The protective effect in the colon may be limited to proximal colon cancers (RR=0.58; 95% CI 0.46 to 0.74) as results for distal colon cancer did not reach statistical significance (RR=0.77, 95% CI 0.58 to 1.04). 14 Increases in dosing, frequency and duration of intake were all independently associated with a decreased risk (RR ranging from 0.80 to 0.84), but were based on only one meta-analysis. 12 Meta-analyses of low-dose aspirin (up to 325 mg/day) found conflicting result

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Indeed, a significant dose–effect for any increment of 100 g/day was reported by Aune et al 34 (RR=0.89; 95% CI 0.81 to 0.98), whereas results from Vieira et al 26 failed to reach statistical significance either for CRC, colon cancer or rectal cancer.

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