Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries.

In relation to circumferential residual stress in aorta artery ( Figure 6A ), which can be quantified by the ring opening angle results, there is a marked trend to decrease its value when the ANP and Cinaciguat treatments are applied, where this difference is noticeable marked in the PAA zone, with statistically significant differences in both treatments.

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Therefore, from the pre-stretching and ring opening tests, there is a clear trend to relaxation of the vascular tissues when any of the treatments is applied, which is a desirable outcome to decrease the effects of hypoxia-induced pulmonary hypertension.

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