Abnormally low prolactin levels in schizophrenia patients after switching to aripiprazole in a randomized trial: a biomarker for rebound in psychotic symptoms?

However, there remained an increasing trend of having a rebound in psychotic symptoms (0.71 for males and 0.46 for females).

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Our results indicated that an abnormally low PRL would be associated with a rebound in psychotic symptoms that was defined using the less stringent criterion (aOR = 4.42, 95% CI: 1.29–15.2) and a relative criterion (aOR = 5.27, 95% CI: 1.33–20.9), but did not reach statistical significance with the rebound defined using the more stringent criterion (aOR = 2.89, 95% CI: 0.71–11.8), possibly due to the small number of patients meeting the criterion of abnormally low PRL.

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The association between abnormally low PRL and rebound in psychotic symptoms failed to reach statistical significance, though the direction of the effect size estimates (1.3 for model 1 and 1.54 for model 2) was consistent with the original.

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