Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy.

During the transition to ambient light, the DM no DR group also showed a trend of attenuation in AFI rise that did not reach statistical significance, while the mild NPDR participants demonstrated a qualitative trend of complete reversal of AFI responses across all three layers that was significantly decreased in the DCP at 5 min compared to controls ( Figure 6 ).

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