Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review.

Cells · 2020 · PMC7694190 · PMID 33158106

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did not reach statistical significanceno p-value reported

Moreover, a study in a rat coronary ligation model of CHF reported α 1D -AR mRNA to be decreased; a numerical reduction of α 1A - and α 1B -AR mRNA did not reach statistical significance [ 2 ]. 4.2.2.

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failed to reach statistical significanceno p-value reported

The results from the V-HeFT trial [ 158 ] further support the detrimental effects of α-blocking therapy-, since prazosin use gave a signal for possibly increased mortality that failed to reach statistical significance.

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