Prognostic and predictive significance of nuclear HIF1α expression in locally advanced HNSCC patients treated with chemoradiation with or without nimotuzumab.

Br J Cancer · 2020 · PMC7722894 · PMID 32939054

Europe PMC DOI

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0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

showed a trendP = 0.053so close (0.05 < p ≤ 0.1)

Unadjusted analyses using the median cut point showed that the low HIF1α expression was significantly associated with better LRC [HR (95% CI) = 0.58 (0.38–0.89), P = 0.011] as well as OS [HR (95% CI) = 0.62 (0.42–0.91), P = 0.016], and showed a trend towards improved PFS [HR (95% CI) = 0.69 (0.47–1.01), P = 0.053, Fig. 2a–c ].

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did not reach statistical significanceno p-value reported

Similar improvement in PFS was also observed in patients with high HIF1α and low-membrane EGFR with NCRT versus CRT [HR (95% CI) = 0.52 (0.28–0.96), P = 0.036]; however, the improvement in LRC [HR (95% CI) = 0.57 (0.29–1.09), P = 0.088] and OS [HR (95% CI) = 0.60 (0.33–1.10), P = 0.097] did not reach statistical significance.

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