Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels.

Since FGF23 also regulates vitamin D metabolism, we performed a real-time PCR analysis on the kidney and found that the expression of Cyp24a1 and Cyp27b1 was decreased and increased, respectively, in Pten ocy −/− mice, although the difference in Cyp27b1 expression did not reach statistical significance (Fig. 3 d).

also in 111,027 other papers

Since Pten expression in the terminal ileum showed a trend toward decreased expression, we performed immunohistochemical analysis of PTEN in the terminal ileum and found the comparable PTEN expression between control and Pten ocy −/− mice (Fig. 1 e).

also in 53,322 other papers