The TRIFLOW study: a randomised, cross-over study evaluating the effects of extrafine beclometasone/formoterol/glycopyrronium on gas trapping in COPD.

Respir Res · 2020 · PMC7727250 · PMID 33298062

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

failed to reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

There were also significantly greater treatment differences in favour of BDP/F/G for Fres, AX and X5, while ∆X5 failed to reach statistical significance (p = 0.06).

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highly significantno p-value reported

Nevertheless, many of the p values reported were highly significant, arguing against the presence of false positives due to multiple testing.

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did not reach statistical significanceno p-value reported

Trough RV improvement was greater for BDP/F/G compared with BDP/F, (− 179 mls; p = 0.0097), while the treatment difference for trough FEV 1 (65 mls; p = 0.08) did not reach statistical significance (see Additional File 1 ).

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