Several associations related to what was observed in the NKCC1 patients were found to be nominally significant ( P < 0.05) in this analysis, including dyshidrosis, chronic bronchitis, and intestinal obstruction (see Table 4 ).
With a subset of transporters located on the wrong membrane in salivary gland, it was surprising that pilocarpine-induced saliva secretion was only reduced by 10% in heterozygous NKCC1-DFX mice compared to wild-type mice; a difference that did not reach statistical significance. 91 The absence of a salivary gland phenotype contrasted with the NKCC1-DFX patient who suffers from dry mouth and who often chew ice to keep her mouth hydrated. 80 Note that the contribution of NKCC1 to saliva production is also different in the different salivary glands, with highest contribution