Immune Status Against Hepatitis B in Patients After Allogeneic Hematopoietic Cell Transplantation-Factors Affecting Early and Long-Lasting Maintenance of Protective Anti-HBs Titers.

A time of immunization ≥24 months after HCT (the late vaccination group) was inversely associated with weak response (OR= 0.43, 95% CI: 0.04–3.5; p= 0.4), but the effect did not reach statistical significance.

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In multivariate analysis, there was only a slight trend toward less common weak responses to immunization with rHBsAg in the late vaccination group.

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Patients with severe cGVHD showed a trend toward lower median Ab titers, although they required a higher rate of booster vaccine doses.

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