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CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response.

J Exp Med · 2021 · PMC7748821 · PMID 33326020

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showed a trendno p-value reported
At day 40 after the first boost, Tfr cell–deficient mice showed a trend of reduced HA stalk–specific IgG titers compared with their wild-type counterparts ( Fig. 5 B ).

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The total serum IgG concentrations were higher in the Tfr cell–deficient animals compared with the controls, though the differences did not reach statistical significance ( Fig. 2 F ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.