At day 40 after the first boost, Tfr cell–deficient mice showed a trend of reduced HA stalk–specific IgG titers compared with their wild-type counterparts ( Fig. 5 B ).
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CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response.
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The total serum IgG concentrations were higher in the Tfr cell–deficient animals compared with the controls, though the differences did not reach statistical significance ( Fig. 2 F ).