Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data.

Biomed Res Int · 2020 · PMC7755470 · PMID 33381579

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showed a trendno p-value reported

The first showed a trend for the negative prognostic effect of DCR2 methylation, failing to reach statistical significance mainly because of the small sample size in this cohort (17 patients) [ 44 ], while the included study was able to demonstrate statistical significance where patients with DCR2 methylation had a worse outcome than patients with unmethylated DCR2 (56% versus 96%, respectively; p < 0.001) [ 49 ].

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did not reach statistical significanceno p-value reported

The hazard ratio of this analysis was 2.4 (95% CI, 0.6–9.2); although this association did not reach statistical significance, these findings show that the methylation status of RASSF1A in the serum of patients with neuroblastoma may have the potential to become a prognostic predictor of outcome.

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