Where Does Metformin Stand in Modern Day Management of Type 2 Diabetes?

Pharmaceuticals (Basel) · 2020 · PMC7761522 · PMID 33261058

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did not reach statistical significanceno p-value reported

Although, there was also a trend towards reduced microvascular endpoints with metformin therapy, however it did not reach statistical significance.

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showed a trendno p-value reported

Metformin and DPP4 Inhibitors Meta-analysis of the three major CVOTs examining DPP4 inhibitors [ 84 , 85 , 86 ], showed that baseline metformin users experienced a trend towards improved cardiovascular outcomes when combined with DPP4 inhibitors (HR 0.92, 95% CI 0.84, 1.01) compared to baseline metformin non-users who in fact showed a trend towards harm (HR1.10, 95% CI 0.97, 1.26) [ 89 ].

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