Modulating the Heat Sensitivity of Prostate Cancer Cell Lines In Vitro: A New Impact for Focal Therapies.

Regarding the downregulated genes, there was a clearly significant enrichment showing a neuroendocrine de-differentiation of the VCaPrev cells ( Figure 6 b; NES −2.2607458, FDR < 0.0001).

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RNA Sequencing of VCaP and VCaPrev Reveals a Highly Significant Enrichment of Genes Normally Repressed by H3K27me3 in VCaPrev Cells In order to investigate possible reasons for the difference in heat response between VCaP and VCaPrev cells, we next did RNA sequencing of these cell lines.

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This shows a clear trend; however, the analysis failed to reach significance (FDR 0.397).

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