44 Another study by Wang et al 45 found weak but consistent evidence of a protective effect of haplogroup E1b1b1c in chromosome Y in all studies with a nominally significant metaanalysis.
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A review of studies examining the association between genetic biomarkers (short tandem repeats and single-nucleotide polymorphisms) and risk of prostate cancer: the need for valid predictive biomarkers.
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In addition, they found a significant trend in the odds ratio from genotype A/A to genotype G/G between low-grade disease and high-grade disease.