Hypoxia Inducible Factor-1alpha (HIF-1A) plays different roles in Gallbladder Cancer and Normal Gallbladder Tissues.

Kaplan-Meier analysis of GBC patients with HIF-1A + [median 10 months, mean 13.281 ± 1.612 months] showed a trend of shorter overall survival (OS) than that of HIF-1A - patients [median 13 months, mean 15.587 ± 1.400 months, p = 0.178, Figure 7 a ].

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Furthermore, we compared MVD in HIF-1A positive or negative samples and found that in GBC samples, the MVD in HIF-1A + group (147 ± 9.828) were higher than that in HIF-1A - group (119 ± 10.290, p = 0.052, Figure 5 a ), although the difference did not reach statistical significance.

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