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Poly(lactic-co-glycolic Acid) Nanoparticle Encapsulated 17β-Estradiol Improves Spatial Memory and Increases Uterine Stimulation in Middle-Aged Ovariectomized Rats.

Front Behav Neurosci · 2020 · PMC7793758 · PMID 33424559

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showed a trendno p-value reported
Indeed, weekly E2 PLGA treatment resulted in improved spatial working memory on the WRAM task and showed a trend in improved spatial reference memory on the MWM task relative to control treatment, whereas free E2 treatment did not impact spatial learning and memory relative to control treatment.

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The blank-PLGA group tended to make more WMC errors on the delay trial compared to the baseline trial, although this did not reach statistical significance [ F (1, 9) = 3.120, ns; Figure 6 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.