Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5.

Similar to its expression in lung tissues, levels of Lox mRNA were increased in the high h IGFBP-5 expressor group as compared with the low expressor group, although the difference did not reach statistical significance ( p = 0.068).

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As seen in Supplemental Figure S7A , gene expression levels of Il-6 showed an increasing trend in lung tissues of mice expressing high levels of transgene, while its levels were comparable in skin tissues ( Supplemental Figure S7B ).

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Furthermore, BLM treatment increased expression levels of the ECM genes Col1a1 , Col3a1, and Fn, and these levels showed a trend of further increase in heterozygous and homozygous mice treated with BLM as compared with wild-type mice treated similarly ( Figure 8 C–E), suggesting that h IGFBP-5 transgene expression potentiated the response to BLM. 2.8.

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