Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma.

Interestingly, an increased in outflow facility was observed in CTSB ko mice compared to CTSB control, although it did not reach statistical significance ( Figure 6 B, CTSB ko : 5.155 ± 1.836 nl/min/mmHg vs.

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The fact that despite the increase in SMA and diminished pro-UPA activation CTSB ko mice showed a trend in higher—than rather lower—outflow facility and no significant morphological or physiological changes in the outflow pathway tissues was somehow a little disappointing and unexpected.

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