Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality.

Transl Psychiatry · 2021 · PMC7801457 · PMID 33431810

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

approached significancep = 3.39 × 10 −6actually significant

Multivariate SD–gene interaction analysis in participants of african descent In the Yale-Penn participants of African descent, we observed the HGF gene survived Bonferroni multiple testing correction for the StructLMM interaction test ( p = 1.08 × 10 −6 ) and approached significance in the association test ( p = 3.39 × 10 −6 ).

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nominally significantno p-value reported

Although we could only conduct limited follow-up analyses due to the weakness of the statistical evidence, we found nominally significant association of HGF gene with the exposure to life-threatening traumatic events in UK Biobank.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.