CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice.

Mol Ther Methods Clin Dev · 2021 · PMC7803634 · PMID 33473359

Europe PMC DOI

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did not reach statistical significanceno p-value reported

A more dramatic reduction was observed in cccDNA levels in anti-HBV AAV- Sa Cas9-treated animals compared with control animals, both before and after entecavir withdrawal ( Figure 5 B), but again this did not reach statistical significance.

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showed a trendno p-value reported

HBV-specific AAV- Sa Cas9 therapy significantly improved survival of human hepatocytes, showed a trend toward decreasing total liver HBV DNA and cccDNA, and was well tolerated.

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highly significantno p-value reported

Treated animals demonstrated a highly significant improvement in human hepatocyte survival compared with control animals.

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