Even if the results did not reach statistical significance, 33% of patients with ASS responded to RTX compared to 9.5% in SSc and 16.7% in MCTD; RTX presented an acceptable safety profile. 38 Among myositis-specific antibodies, antimelanoma differentiation-associated gene 5 antibody (anti-MDA5) is significantly associated with ILD.
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Efficacy and safety of rituximab in the treatment of connective tissue disease-related interstitial lung disease.
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Furthermore, DLCO also showed a trend in improvement in the RTX group.