Transcutaneous carbon dioxide pattern and trend over time in preterm infants.

Examining the raw data revealed that there is a clear trend to decreasing pCO 2 with increasing PMA ( p = 0.03; Fig. 1 ).

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Studies randomizing infants to moderately higher pCO 2 targets (permissive hypercarbia) have shown no difference in morbidities between groups, but those targeting even higher levels showed a trend toward increase in rates of IVH and periventricular leukomalacia (PVL). 17 , 29 , 31 , 41 Despite clinical use of permissive hypercapnia and less invasive ventilation, our cohort had extremely low rates of IVH; only 1.9% had severe IVH and no infants were diagnosed with PVL.

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