Interestingly, although the risk of COVID-19 infection between sexes was only marginally significant (OR, 1.15; P = .021), males were at a substantially higher risk of requiring ventilation (OR, 2.99; P = 1.6 × 10 −8 ).
We tested whether the lack of significance may be due to insufficient power by combining it with the other immune-mediated diseases that fell shy of significance (asthma, COPD, inflammatory bowel disease, and type 1 diabetes), but the combination of inflammatory diseases still had no significant impact on the risk of ventilation (OR, 1.06; P = .772), even though it included almost twice as many COVID-19 samples as “Any Skin Condition” (460 compared with 251), suggesting the observation is not due to lack of power.