Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies.

Nonetheless, the result on bipolar disorder [ 113 ] was not confirmed by an earlier study [ 107 ] where MR using only CRP gene SNPs did not reach statistical significance at P < 0.05.

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It is a Chi square-based test that assesses whether the observed number of studies with nominally significant results is larger than their expected number.

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