Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia.

1e ), with 19 showing significant differences in methylation between first treatment and relapse, and a further three approaching significance ( P FDR < 0.085) (Table 1 ).

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5 Of the 22 validated CLL-specific DMRs, 16 associated genes were differentially expressed between timepoints ( P FDR < 0.05), while a further gene, RNF144A , approached significance ( P FDR < 0.10).

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