Mutation in the distal NPxY motif of LRP1 alleviates dietary cholesterol-induced dyslipidemia and tissue inflammation.

Chow-fed LRP1 NPxY mutant mice also showed a trend of lower plasma cholesterol levels than wild-type mice when the animals were fed the LF/low-cholesterol chow diet, but the difference did not reach statistical significance ( Fig. 3 B).

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For example, data from the Genetics of Lipid Lowering Drugs and Diet Network revealed a highly significant relationship between LRP1 polymorphism and body mass index ( 2 ).

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