Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection.

The group treated with the low-dose vaccine alone had 80% survival rate, which did not reach statistical significance compared with the infected untreated control group (Table 1 ).

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While mice vaccinated with either a high or low-dose of the vaccine alone or E6020-SE alone showed a trend to a lower parasitemia compared to infected untreated controls, these reductions did not reach statistical significance (Fig. 1 A,B).

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