Evaluation of Serum Leucine-Rich Alpha-2 Glycoprotein as a New Inflammatory Biomarker of Inflammatory Bowel Disease.

Among patients with CD, serum LRG levels showed a trend toward lower levels in those with anti-TNF- α treatment ( n = 59) than in those without anti-TNF- α treatment ( n = 37) ( Figure 6 ); additionally, in those with anti-TNF- α treatment, the LRG level was correlated with several laboratory and disease activity markers (Table S5 ).

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Furthermore, we assessed, for the first time in CD, endoscopic disease activity in relation to LRG levels and found that LRG tended to correlate with endoscopic disease activity as assessed by SES-CD, but the correlation did not reach statistical significance.

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