JNK1 ablation improves pancreatic β-cell mass and function in db/db diabetic mice without affecting insulin sensitivity and adipose tissue inflammation.

Relatively to db/db mice, db/db‐JNK1 −/− mice showed a trend toward increased β‐cell proliferation, which may explain the beneficial effects of JNK1 ablation on insulin levels and β‐cell number in db/db mice, but this difference did not achieve statistical significance.

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We observed an overall tendency for db/db‐JNK1 −/− mice to display lower glucose levels than control db/db mice, but this difference did not reach statistical significance (Figure 1B ).

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