Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma.

Overall, 16,835 of 17,698 genes showed a trend of decreasing modification level of 5hmC in FL than DLBCL, and 50% of the total 5hmC differential modification between DLBCL and FL was driven by a small proportion of genes (~10%) (Fig. 1d ).

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Overall, the 5hmC reads within these four signature genes showed a significant trend of co-localizing with histone modifications that mark enhancers and active expression (i.e., H3K4me1and H3K27ac), compared to repression markers (i.e., H3K27me3 and H3K9me3) (Fig. 3a ).

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