Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.

CP2-treated male 3xTg-AD mice showed a trend toward an improvement in comparison to their vehicle-treated counterparts ( Fig. 2G,H ).

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In male mice, these changes did not reach statistical significance and, apart from GSK3β, were showing only trends.

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