Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons.

There was a significant main effect of treatment upon filopodia density, with a significant increase following TTX application only, and a strong trend to an increase following total silencing ( Figure 3Cii ).

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While filopodia density was not significantly altered, there was a clear trend toward TTX treatment increasing filopodia in a dose/time-dependent manner ( Figure 2Cii ).

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