Image analysis in the cortex and hippocampus of 6-mo-old PSAPP mice (prophylactic group) showed a highly significant (greater than twofold; P < 0.01) attenuation of cerebral amyloidosis by chronic treatment with compound 2 ( Fig. 7, A and B ).
Another MAD study involved the GSM NGP555, which showed a trend toward increasing ratios of Aβ37/Aβ42 and Aβ38/Aβ42 in CSF at doses of 200 mg and 400 mg, but without demonstrating statistical significance ( Kounnas et al., 2019 ).
Treatment of 6-mo-old PSAPP transgenic mice with compound 2 (25 mg/kg/d po) for 3 mo also resulted in decreases in plasma Aβ42 and Aβ40 levels and potentiation of Aβ38 levels, although the differential effects on plasma Aβ40 and Aβ38 levels did not reach statistical significance ( Fig. 5 D ).