The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis <i>In Vitro</i> and Induces Vasodilatation Without Desensitisation <i>In Vivo</i>.

Although this study was limited by the number of animals that could be used and a high variance in the 50 nmol [Pyr 1 ]apelin-13 responses, there is a clear trend across the parameters.

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CMF-019 at 10 μM displayed no significant rescue despite trending towards significance (4.38 ± 1.48%, ns) ( Figure 3 ).

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