Interestingly, quantification of alpha smooth muscle actin demonstrated higher basal arteriolar density in HFD swine compared with their ND counterparts; whereas EVs were associated with increased CD31‐labeled endothelial cell density only in the ND tissue, which approached significance.
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Effects of High Fat Versus Normal Diet on Extracellular Vesicle-Induced Angiogenesis in a Swine Model of Chronic Myocardial Ischemia.
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We observed that increased CD31‐labeled endothelial cell density in response to EV treatment in ND animals was absent in HFD tissue and did not reach statistical significance (Figure 3B ).