Although previous data indicate PAR1 KO have an improved NSS following stroke [ 19 ], in the present study this effect did not reach statistical significance.
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Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume.
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Thrombin activity showed a trend towards decrease in the non-ischemic hemisphere of the PAR1 KO as well ( Fig 3C ) with spatial variations ( Fig 3D ).