Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage.

A decreasing trend in WBC and lymphocyte counts was observed in male and female rats; however, no pair-wise differences occurred ( Table 3 ).

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A negative trend, but no pair-wise differences, in erythrocyte counts was observed in both male and female rats.

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In the micronucleus assay, a positive response is preferably based on the observation of both a significant trend as well an observation of at least one dose group significantly elevated over the concurrent control group.

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