Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants.

Front Mol Neurosci · 2021 · PMC7991399 · PMID 33776648

Europe PMC DOI

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0.3300

closest p · 6.6× alpha

0.3300

boldest claim

The sentences

did not reach statistical significancep = 0.33not close (p > 0.1)

The density of GFP + SGNs ( Figure 2C ) tended to be higher for AAV2/6 (2.86 ± 0.44 SGNs/10 4 μm 2 , transduction rate = 17.39 ± 2.64%) than for AAV-PHP.B (1.85 ± 0.51 SGNs/10 4 μm 2 , transduction rate = 12.99 ± 3.85%), which however did not reach statistical significance ( p = 0.33, Wilcoxon rank sum test).

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showed a trendno p-value reported

Cochleae injected with AAV2/6 showed a trend to a higher number of transduced SGNs compared to AAV-PHP.B, similar SGNs density but fewer oABR positive gerbils.

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