Combined COX-2/PPARγ Expression as Independent Negative Prognosticator for Vulvar Cancer Patients.

Diagnostics (Basel) · 2021 · PMC8001561 · PMID 33802010

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

a negative trendp = 0.053so close (0.05 < p ≤ 0.1)

In comparison, the expression of PPARγ in the cytoplasm is associated with a negative trend in overall survival ( Figure 4 , image B, p = 0.053). 3.4.

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highly significantno p-value reported

Hence, our observation that COX-2 in the cytoplasm is a highly significant independent prognostic factor for the overall survival of our patient population is even more interesting.

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an unfavorable trendno p-value reported

These findings would explain the opposite effect on survival when PPARγ is detected in the nucleus or in the cytoplasm: Nuclear expressed PPARγ is a prognostically favorable factor in overall survival, but detection in the cytoplasm is a prognostically unfavorable factor in disease-free survival and shows an unfavorable trend in overall survival.

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