Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects.

PEA abolished the atypical hyperactivity induced by LPS and, in some cultures, it even showed a trend to reduce the network activity compared to control condition.

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To further strengthen these hypotheses, N9 cells were treated with 100 μM PEA alone for 1 h ( Figure S1 ), and results demonstrated a trend toward an increase in Arg1 levels, even if it did not reach statistical significance.

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